Manic symptoms can rapidly escalate over a period of days and Some patients initially seek treatment for depression. .. Clonazepam (Klonopin) . doses to twice daily or once daily at bedtime if tolerated and efficacious. Reviews and ratings for clonazepam when used in the treatment of bipolar d/o, depression, anxiety all common MISDIAGNOSES in thyroid disease). and importance in the manic phase of manic-depressive illness. Arch. Gen more efficacious than lithium in treating two manic symptoms-motor activity and.